Researchers from Denmark have uncovered a potential link between oral contraceptive use and instances of ACL injuries that required surgical intervention in women. The researchers evaluated 4,497 women who were treated operatively for an ACL injury between July 2005 and December 2011 and 8,858 age-matched, uninjured controls.
Data in the operative cohort were culled from the Danish Knee Ligament Reconstruction Registry, and patients were divided into subgroups based on whether they used oral contraceptives at the time of injury, within 5 years of injury or not at all. Longevity of oral contraceptive usage was also noted, and a dose-response analysis was performed for all patients who had used oral contraceptives. Relative risk of sustaining an ACL injury requiring surgical treatment according to OC use was determined via conditional logistic regression analysis.